Funding Research

Funding Research

$2.6 Million Committed and Counting

The Team Jack Foundation is focused on raising money for pediatric brain cancer research.  Because of your support, and the support of all of the incredible donors from all across the country, the Team Jack Foundation has committed $2,600,000 to pediatric brain cancer research since it's inception.  This includes research currently ongoing, as well as new projects that have been developed for investment by the Foundation. 

Project 1: Drug Efficacy, Genetic Mutation Identification

Project 1: Drug Efficacy, Genetic Mutation Identification
Project 1: Drug Efficacy, Genetic Mutation Identification

The Team Jack Legacy Fund by CureSearch (the predecessor to the Team Jack Foundation) awarded a $275,000 research grant to the prestigious Dana Farber Cancer Institute/Harvard Medical School to help fund translational and innovative pediatric brain cancer research in January of 2013.  This research project is analyzing the efficacy of cancer drug delivery to a tumor site so as to determine whether or not efficacy is being achieved.  This project will analyze the molecular structure of existing cancer medications and re-engineer them so that they can get past the blood-brain barrier and to the tumor site for treatment efficacy. Other aspects of the project include the process of identifying other genetic mutations ("oncogenes") in pediatric brain tumors to determine what causes them to grow.  After identifying any new genetic mutations, the project will turn its focus to working towards chemically engineering a "smart drug."

Principal Investigator: Dr. Charles Stiles, Director of Cancer of Biology at Harvard Medical School/Scientist-Dana Farber Cancer Institute

Project 2: Clinical Trial

Project 2: Clinical Trial
Project 2: Clinical Trial

In October 2013, Team Jack made a $300,000 commitment to help fund a pediatric brain tumor clinical trial that is scheduled to begin in January of 2014.  A clinical trial is the usage of a new or existing cancer therapy drug on children.  This particular clinical trial will have both Phase I and Phase II components.  The clinical trial has been approved by the FDA, and with support from Team Jack, researchers are hopeful that enrollment of children can begin soon.  Due to the high cost of the clinical trial, Team Jack will be a co-sponsor of the Clinical Trial, in conjunction with other private Foundations. Check back for exciting announcements regarding Team Jack's support of this exciting clinical trial.

Principal Investigator: Dr. Mark Kieran, Director of Pediatric Neuro-Oncology at Dana Farber Cancer Institute/Harvard Medical School.

Project 3: Neurosurgical Innovation

Project 3: Neurosurgical Innovation
Project 3: Neurosurgical Innovation

As chemotherapy and radiation treatments continue to receive the bulk of the research investment, there is a third aspect of brain tumor treatment that must not be forgotten about. Recognizing the unique position that the Team Jack Foundation is in to make a permanent and substantial difference in the fight against pediatric brain cancer, one of the top pediatric neurosurgeons in the world has developed an exciting research initiative which includes the development of a surgical instrument that is certain to change the landscape of not only pediatric brain cancer surgery, but also adult brain tumor surgeries, and eventually all cancer surgeries.  It is widely recognized that the first best step, and often times the determining factor in determining whether a brain tumor can be survived, is whether the brain tumor is surgically removed.  But it is not enough that a tumor just be removed.  It must be safely removed. Neurological deficits are frequently the result of an aggressive brain tumor removal surgery. Complete and safe brain tumor removal surgeries is the focus of this cutting edge research project. The Team Jack Foundation has committed $500,000 to help fund this cutting-edge research project, and will serve as one of the lead Foundations in helping raise additional funds for this important research.

Principal Investigators: Dr. Liliana Goumnerova, Chief of Pediatric Neuro-Oncological Surgery at Boston Children's Hospital / Dana Farber Cancer Institute / Harvard Medical School in conjunction with engineering support from the Massachusetts Institute of Technology (MIT).

Project 4: Medulloblastoma Acceleration Project

Project 4: Medulloblastoma Acceleration Project
Project 4: Medulloblastoma Acceleration Project

The Team Jack Foundation is currently working with a fellow private Foundation partner in serving as a participating partial sponsor on a very exciting research project relating to a specific type of pediatric brain cancer known as Medulloblastoma.  

Principal Investigator: William Weiss, MD, PhD at the University of California, San Francisco

Project 5: Team Jack Foundation - University of Nebraska Medical Center (UNMC) Pediatric Brain Tumor Program

Project 5: Team Jack Foundation - University of Nebraska Medical Center (UNMC) Pediatric Brain Tumor Program
Project 5: Team Jack Foundation - University of Nebraska Medical Center (UNMC) Pediatric Brain Tumor Program

The Team Jack Foundation, in partnership Nebraska State Legislature, will commit to a $3 million project for the development of a pediatric brain tumor program at UNMC’s Fred & Pamela Buffett Cancer Center.  Board Chair of the Team Jack Foundation, Andrew Hoffman, testified for LB 110, a legislative bill to appropriate funds for pediatric cancer specialists, at the Nebraska State Legislature's Appropriations Committee Hearing at the 2015 legislative session.  Included in the appropriation are funds to support two additional pediatric cancer specialists.  The funds appropriated by the legislation will be utilized to leverage additional private funding.  The Team Jack Foundation has committed to raising $1.5 million over six years to match these funds. Plans are currently underway in the development of this ground breaking program.  

Additional Insights

Additional Insights
Additional Insights

The Team Jack Foundation is committed to helping find a cure for pediatric brain cancer. Team Jack will work closely with its scientific advisory board

Research is needed to improve drug delivery methods, as well as identifying other possible genetic abnormalities in pediatric brain cancer that can be treated with chemically engineered "smart drugs."

The Team Jack Foundation is committed to helping defeat the No. 1 cancer cause of death in children.  

The Team Jack Foundation invites all pediatric brain tumor researchers to inquire about research grants for pediatric brain cancer research.  Other Foundations supporting pediatric brain cancer research are encouraged to share their research investment opportunities with Team Jack so as to identify possible collaborative opportunities.